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Rather than resolving hypoxia, these factors activate the expression of genes involved in anaerobic glycolysis (e.g., GLUT1, HK2, LDHA), angiogenesis (e.g., VEGF), invasion (e.g., MMP2, MMP9), and stem cell maintenance

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Finally, nine articles that investigated the current knowledge on substances that have or may affect the brain at the cognitive level in the context of sports were included in the review