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We extend beyond cataloging drugs by contextualizing landmark events such as the first biomarker-driven accelerated approval (tofersen) and a major Phase 3 trial failure leading to market withdrawal (AMX0035) to discuss their implications for clinical trial design and therapeutic strategy

The study reveals that echinatin reduced ECM stiffness surrounding cultured VSMCs and upregulated glutamate cysteine ligases (GCLs) expression, including the catalytic (GCLC) and regulatory (GCLM) subunits

DOI.org (Crossref) , Antioxidants , vol

363 Interestingly, in aging tissues, the inhibition of key molecules with high activity in oxidative stress and strong ROS inducers, such as p38, can restore the function of HSCs

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Ai-based phenotyping of hepatic fiber morphology to inform molecular alterations in metabolic dysfunction-associated steatotic liver disease