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Lets deal with the simpler one firstthe presence of cysteine
It is not clear whether findings in rodent studies are applicable to humans
The determination of the rate constants for the reaction of DSePA with hydroperoxides versus thiols, along with the characterization of reaction intermediates, suggested that the entry of DSePA into the GPx cycle followed an oxidative rather than a reductive pathway (Fig
NO-system over-stimulation vs
10.1016/j.neuroscience.2018.03.008 358 WangJ.XuG.BorcheltD
This tissue has one of the highest oxidative metabolic rates per tissue mass in the human body
