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Stephanou Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

Furthermore, designing constructs with transient CAR expression, drug-induced on/off switches, and Suicide switches mechanisms can be helpful in restricting the CAR-T cell derived toxicities