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Improved brain growth and microstructural development in breast milk-fed very low birth weight premature infants

In preclinical studies, metformin activates AMPK via inhibition of mitochondrial complex I, enhancing mitochondrial biogenesis and mitophagy [148], while pioglitazone promotes fatty acid oxidation, energy production, and reduces neuroinflammation [149]

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A comprehensive 2025 analysis published in the Proceedings of the National Academy of Sciences (PNAS) evaluated patient-reported outcomes for various treatments in post-viral dysautonomia and ME/CFS cohorts

Another study also confirmed that fish oil is more effective than flaxseed oil in regulating intestinal microflora and reducing TMAO-exacerbated atherogenesis (88)

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