glp 1 drugs definition The promise and peril of GLP-1 agonists: What we do (and don't) know as of August 2024 What is GLP-1 & Does

Injectable GLP-1 agents continue to provide strong efficacy and established cardiovascular benefits with convenient weekly administration

The medications generating headlines for dramatic weight loss results

But with list prices of roughly $1,000 a month, public and private payers are struggling to keep up with ballooning demand for GLP-1 weight loss drugs and in some cases are eliminating or restricting their coverage as a result

They act partly by imitating a gut hormone involved in appetite regulation, insulin secretion and blood glucose control

There was no difference in severe hypoglycaemia, genital candidiasis, acute pancreatitis, or gastrointestinal upset (nausea, vomiting and diarrhoea) between the two groups

One article found an increased incidence of aspiration pneumonia among GLP-1 users compared to non-users reporting a hazard ratio of 1.33 (95%CI 1.021.74, p = 0.036) (Australian Diabetes Society, National Association of Clinical Obesity Services, Gastroenterological Society of Australia, and Australian and New Zealand College of Anaesthetists n.d.)