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In vitro hepatic models suggested that flavonoids and sulfur-containing compounds in garlic supplements might interfere with the activity of efflux drug transporters of the ATP-binding cassette (ABC) family, including P-glycoprotein, multidrug resistance protein (MRP), and breast cancer-resistance protein (BCRP), which function as ATP-dependent efflux pumps that actively regulate the excretion of a number of drugs limiting their systemic bioavailability

erythematotelangiectic, papulopustular, phymatous, and ocular rosacea.1 The most common manifestation is erythematolangiectatic rosacea, which presents in approximately 57% of patients with rosacea, and papulopustular rosacea, which presents in approximately 43% of patients with rosacea

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Continuous administration does not seem to provide additional benefit and may actually diminish the compound's effectiveness over time

Restarting after missed doses can therefore recreate part of the escalation burden