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Discussion VCD, characterized by an impaired ability to visually perceive and construct complex visual-spatial designs or tasks, is a well-recognized feature of aging-related neurodegenerative diseases, including Alzheimers disease 26

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Hyperinsulinemia and ectopic lipid accumulation promote activation of pro-inflammatory pathways, including Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-B) signaling and NLRP3 inflammasome activation, which in turn exacerbate loss of immune tolerance [52,53]

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doi: 10.1615/CritRevImmunol.v31.i5 [DOI] [PubMed] [Google Scholar] 218