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Oxidative stress and ascorbate in relation to risk for cataract and age-related maculopathy

This immunosuppressive environment is maintained by several cytokines such as IL-6 and TNF-, which activate NF-B/STAT3 signaling, and chemokines such as CCL2 and CXCL12, which bring in monocytes (107, 108)

Moreover, properly harnessing the Nrf2/HO-1 axis while managing its potential pro-ferroptotic risks may help maintain redox balance and curb iron overload, thereby offering an additional strategy to alleviate ferroptosis-driven damage in OA (202)

10.1038/s42255-024-00974-4 38 LeeJ.YooI.AhnI.LeeN

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