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(jofem.org) But it is not in the same efficacy universe as GLP-1/GIP medications for weight loss, and it should not be positioned that way

Theoretical concerns Ectopic fat deposition

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These short-acting satiety and hunger signals are transmitted via afferent fibers of the vagus nerve to the caudal brainstem in nucleus tractus solitarius, from where they also influence the hypothalamus

Tirzepatide causes gastrointestinal symptoms including nausea, vomiting, diarrhea, and constipation in a substantial percentage of users, particularly during dose escalation phases