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Inflammation is discussed in a separate article

References and Further Reading Chang, C

The single human musculoskeletal paper that gets cited often is a small retrospective case series of intra-articular BPC-157 injections for multiple types of knee pain. It reported improvement in 11 of 12 patients, but the study has major limitations: no control group, no standardized objective outcome measures, no imaging confirmation of pathology, and unclear diagnostic specificity

They sit near the top of the evidence hierarchy, just below meta-analyses (which combine multiple RCTs)

Consequently, whilst it is clearly a key component in the diet and there may be potential for supplementation to have beneficial effects, evidence to support the administration of tryptophan above and beyond what can be consumed in a healthy diet is currently lacking and further investigation is required

10.1172/JCI122258 25 CarneiroB