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Recent advances in understanding leptin signaling and leptin resistance

Due to the recent nature of this disease no treatments have shown complete efficacy and safety

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That is a deficiency being corrected, not a boost above normal

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Given the ability of tesofensine to modulate the activity of the LH, our preclinical findings agree with the proposal that tesofensine could be a useful treatment for patients with hypothalamic obesity, a rare feeding disorder, as recently demonstrated [38]