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Each year, approximately 1 in 10,000 people develops bursitis in the elbow or knee alone and the hip, shoulder, and heel are affected just as often

Moreover, depleting senescent retinal cells has been shown to protect the RGCs in experimental glaucoma 18

The presence of insulin resistance and elevated pro-inflammatory cytokines (e.g., tumor necrosis factor-) induce hepatic GH resistance (64), causing increases in GH and decreases in IGF-I levels ( Table 1 )

Of interest, patients with metabolic diseases, such as obesity and type 2 diabetes 35 have been reported to have a reduction of bacterial riboflavin synthesis genes in their gut microbiome, suggesting that microbially-produced riboflavin could play a role in these diseases, although the causal association remains to be established

2e and f and Supplementary Fig

doi: 10.1016/j.foodchem.2017.08.105 20