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Description
The strongest GlyNAC trial in humans enrolled 24 older adults

Endocrinology 142 , 10981106 (2001)

10.1016/j.neulet.2022.136493 55 LiuL.FengD.ChenG.ChenM.ZhengQ.SongP.et al (2012)

Rational design of polymeric micelles for targeted therapeutic delivery

Severe phenotype in patients with large deletions of NF1

Recent studies in the rat model of WD, found that methanobactin, a peptide produced by proteobacterium Methylosinus trichosporium , can be successfully used to remove excess Cu from mitochondria, decrease liver histopathology, and prevent liver failure ( Since dysregulation of nuclear receptors, especially LXR and FXR, contribute significantly to WD phenotype (see above), targeting these receptors, could be an attractive alternative option for patients who do not respond or poorly tolerate Cu chelation
