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Beyond its antioxidant function, glutathione plays critical roles in immune system regulation supporting T-cell proliferation and natural killer cell activity

Treatment of rat enterocytes, renal cortical tubules, or hepatocytes with propargylglycine to inhibit CSE resulted in inhibition of sulfur anion production or overall catabolism of Cys by about 50% (Drake et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Adler G.L., Le K., Fu Y.H., Kim W.S

This may especially play a part in understanding the environmental toxicity of heavy metals

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Since the glutamate-glutamine cycle is an open cycle that actively interfaces with other pathways, the de novo synthesis of glutamine in astrocytes helps to maintain the operation of this cycle