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Within the first 2 d of withdrawal, BZDs reduce the incidence of seizures by up to 84% and prevent the development of DT.74 The current literature does not suggest one BZD to be more efficacious than another, although differences in pharmacokinetic properties can guide selection.71, 73, 74, 75 The following recommendations include agents 75 with rapid onset to control agitation symptoms with long action to avoid breakthrough symptoms with less dependence on hepatic metabolism to lower the risk of over sedation Diazepam fulfills the first two aspects and represents the primary choice

Investig Ophth Vis Sci 2012;53:654156

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Pharmacokinetic properties and adverse reactions Advanced technologies have generated NADs complexes with different properties