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Key Points The inflammatory reflex is a physiological mechanism through which the vagus nerve regulates immune function and inhibits excessive proinflammatory cytokine production Vagus nerve signalling has an important role in the regulation of feeding behaviour and metabolic homeostasis Disruption of metabolic and immune regulation in obesity results in inflammation, which mediates insulin resistance and the development of type 2 diabetes mellitus as well as other debilitating and life-threatening conditions Activation of cholinergic signalling in the efferent arm of the inflammatory reflex alleviates obesity-associated inflammation and metabolic derangements The inflammatory reflex can potentially be exploited for treatment of the metabolic syndrome, type 2 diabetes mellitus and other obesity-driven disorders This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 189,00 per year only 15,75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

Many Gram-negative bacteria, such as E

Excitotoxicity of glutamate has a direct effect on the inflammatory injury of neurons [121]

Ganglionic blockers block the open channel pore, and do not interact with the acetylcholine receptor, in contrast to the mechanism of action of non-depolarizing skeletal muscle relaxants such as rocuronium and and vecuronium, which are competitive antagonists of the nicotinic acetylcholine receptor (Giniatullin et al, 2000)

Tepper JS, Kuehl PJ, Cracknell S, et al

Hydroperoxides The 9( S )-hydroperoxide of 9( S )-HpODE 1 (Scheme 53) is conveniently prepared using the LOX enzyme present in tomato fruit