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657 The BBB is composed of tightly packed, non-fenestrated endothelial cells linked by TJs and adherens junctions (AJs), which share a common basement membrane with pericytes and astrocytes

The formation of Hcy is caused by the O-methylation of levodopa which is catalyzed by the catechol-O-methyltransferase (COMT) [126]

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Supporting these findings, the RNA-seq analysis of wild-type (WT) and Abat cKO T cells activated under the T H 0 condition revealed enriched gene signatures associated with inflammation and T cell differentiation (Fig