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The study found that ANKO mice, which lack NAMPT in both brown adipose tissue (BAT) and WAT, showed disturbed gene programs involving thermogenesis and mitochondrial function in BAT, resulting in a dampened thermal response

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(PubMed) Beydoun MA, Beydoun HA, Gamaldo AA, Teel A, Zonderman AB, Wang Y

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Discovery of DS68702229 as a potent, orally available NAMPT (nicotinamide phosphoribosyltransferase) activator