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However, the CVB3-encoded protease, 3C pro , has been shown to attenuate type I IFN signaling by cleaving MAVS and TRIF, another component of the antiviral response, within hours of infection in multiple cell lines (157)

During the entire experiment, the mice were housed under rigorously controlled conditions, including a temperature of 23C 2C, a relative humidity of 45% 5%, and a consistent 12-hour light/dark cycle

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