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doi: 10.3945/an.111.000430

Enclomiphene is a selective estrogen receptor modulator (SERM) that has gained attention as a modern alternative for stimulati

2021 Jan;24(S1):S233-S246

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62 Examples of surfactants are sodium deoxycholate, Cremophor EL, Tween (polyoxyethylene sorbitan monolaurate), Span (sorbitan monolaurate), Solutol HS 15 (polyoxyethylene-660-hydroxystearate), Poloxamer , and sodium dodecyl sulfate

Intranasal administration of the optimized formulation (Cmax = ~ 600 ng/mL, tmax = 0.5 h) exhibited a plasma AUC 0.78 times the AUC of the orally administered product (Cmax = ~ 780 ng/mL, tmax = 2 h), whereas the brain AUC was significantly (3.28 times) higher for intranasal administration (Cmax = ~1240 ng/mL, tmax = 0.5 h) than oral administration (Cmax = ~ 380 ng/mL, tmax = 1 h)