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Systemic chemotherapy (dacarbazine, temozolomide, or carboplatin/paclitaxel) plays a crucial role for some patients with metastatic disease

Genetically-induced HHcy (CBS +/ mice) was associated with a marked reduction in plasma levels of H 2 S, glomerular filtration rate (GFR) and renal cortical blood flow

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In order to determine if effects differed by baseline GSH, changes in GSH after 1, 2 and 4 weeks were correlated with GSH levels at baseline

Yet, whether potential protection conferred by isothiocyanates via the Nrf2-dependent pathway is diminished in individuals carrying GST -/- variants is currently unknown

doi: 10.1016/bs.afnr.2017.11.002 145