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Besides up-regulating the expression of p53 in U251 glioma cells, the initiation of G2/M cell cycle arrest also induced ING4 expression, a novel member of ING tumor suppressor family when curcumin was employed [54] (Fig

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These findings indicate either an upregulation of GPX4 in response to PD pathology, or an increase in survival of cells expressing GPX4, and further suggest a neuroprotective role of GPX4 in PD pathology

Glutathione also works best in the presence of selenium

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