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This intriguing mode of cell response to acute genotoxic stress led Berger (86) to propose the suicide hypothesis of PARP activation, which can be regarded as a way to eliminate cells after irreversible DNA injury

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As with GPCR stimulation, PMNs lacking PI3K fail to produce ROS in response to IgG IC stimulation (Kulkani et al., 2011)

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124 , 1517S1523S (1994)