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Results Thirteen articles were included in our systematic review and meta-analysis
Parkinsons disease (PD) is a common neurodegenerative disorder caused by a spread of misfolded -synuclein and ascending neuronal degeneration mainly in dopaminergic neurons, leading to progressive nigrostriatal dysfunction and disruption of other pathways
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In particular, GSDME-deficiency significantly attenuated the hippocampal atrophy and changed levels of DAM markers in GCLC-KO mice
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