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Another novel orally available LDL-C-lowering drug is bempedoic acid, which lowers LDL-C by approximately 2025% by inhibiting the ATP citrate lyase [74] and is now, after the positive CLEAR outcomes trial has demonstrated cardiovascular benefit, also recommended by the recently updated ESC guidelines for the management of dyslipidaemias for patients with statin intolerance or those not at LDL-C target [39, 74]

LCO ) in two patients ( As explained before, pulmonary fibrosis and especially IPF was linked to an AE2C dysfunction and increased ER stress response due to aberrant protein accumulation

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First MB, Williams JBW, Karg RS, Spitzer RL

'A compound that acts on hormone receptors gets repackaged as a "tanning hack," but biologically it's still a drug affecting real physiological pathways

The correlation between LAL phenotype and genotype is still a matter of disputation in WD and CESD cases