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The low clearance of long-chain acylcarnitine molecules leads to a high acylcarnitine-to-L-carnitine ratio that has been associated with a higher risk of cardiovascular mortality (72)
Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial
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doi: 10.1210/clinem/dgaa057 283
doi:10.1186/s13643-023-02238-w Keller U, van der Wal C, et al
[12] [1] Liu J, Head E, Kuratsune H, Cotman CW, Ames BN
