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Under MPP+ treatment, HIF-1 expression was elevated, and PGC-1 expression was reduced, consistent with ref

Antonoff MB, Kui N, Sun R, Deboever N, Hofstetter W, Mehran RJ, Morris VK, Rice DC , Swisher SG, Vaporciyan AA, Walsh GL, Rajaram R

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10.3390/pharmaceutics14122706 67 JeongJ.LeeH.ChoiJ.KangJ.KimD.ParkC.et al (2025)

However, with that being said, in the study by Akbari Dilmaghani et al 90 it is reported that the treatment group had mild superiority in general health improvement but not in symptoms

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