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NAFLD-like hepatic pathological changes such as steatosis, inflammatory cell infiltration, necrotic hepatocytes, and liver fibrosis, accompanied by increased expression of inflammatory cytokines (TNF-, IL-1), stress-related protein urocortin-1, antioxidant gene glutathione peroxidase-1 (Gpx1), and the NLRP3 inflammasome within the hepatic tissues, have been observed in several rodent models of PCOS (108111)

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Rocha VZ, Libby P

Nevertheless, to further assess the impact of QMP engineering of the GLP-1 albumin fusion on glycemic control and treatment of T2DM, additional studies are needed in relevant disease models

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