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While the lysosomal inhibitor LCL521 disrupts autophagy by activating cathepsin B/D, inducing endoplasmic reticulum stress in MDSCs and promoting their death, providing a basis for therapies targeting MDSC autophagy (112)

Zeng H et al

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Coffee Makes the dehydration worse

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Moreover, muscle-derived cytokines like IL-15 appear to promote NK cell proliferation and cytotoxicity, including against senescent targets (55)
