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Regulates Enzymatic Remodeling During the remodeling phase, GHKCu balances extracellular matrix degradation and rebuilding by modulating matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs)

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In a 2013 study by Korenevsky et al., the researchers administered a combination of melatonin and epithalon to female rats exposed to suboptimal environmental factors, such as light pollution, finding that the combined therapy rectified various impairments of the hypothalamic-pituitary-gonadal axis [13]