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Given the limited evidence, selection among antidepressant classes in this population should be individualized based on the patients comorbidity profile, pain type, and risk factors for adverse effects

To protect RBC function and integrity, robust antioxidant systems are necessary

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doi: 10.1002/ana.24439

These cellular disturbances activate pro-inflammatory signaling pathways, including NF-B and the NLRP3 inflammasome, resulting in increased secretion of cytokines such as IFN-, IL-6, and TNF- [31]

10.3164/jcbn.20-39 92 NguyenP.LerayV.DiezM.SerisierS.Le BlochJ.SiliartB.et al (2008)