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Overall, the available preclinical data suggest that melatonin and its metabolites may reduce metal-induced oxidative stress through both chelation and radical-scavenging mechanisms

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Rouyer A., Tard C., Dessein A.F., Spinazzi M., Bdat-Millet A.L., Dimitri-Boulos D., Nadaj-Pakleza A., Chanson J.B., Nicolas G., Douillard C., et al

Nanoparticle size distribution and zeta potential were measured by a Zetasizer Nano ZS90 nanoparticle size analyzer (Malvern, U.K.)

Anyone considering IV therapy should undergo screening for conditions like glucose 6 phosphate dehydrogenase (G6PD) deficiency, kidney problems, and iron overload

Thanks to its antioxidant effect, it acts directly TNF-, IL-1, IL-6 and IL-8, decreasing the pro-inflammatory cytokines generated during the infection and, finally, reducing platelet aggregation and arterial thrombi thanks to the antithrombotic effect of the drug [32], [54]