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Food and Drug Administration) Dosage and infusion rate : high doses or rapid infusion increase risk of systemic reactions (allergy, shock, organ stress)

110 On the contrary, ABCB8 can facilitate mitochondrial iron export

63 GiulianoC.Pea-OliverY.GoodlettC

Prochazkova J, Sterzl I, Kucerkova H, Bartova J, Stejskal VDM

However, these effects were reversed following the addition of the SIRT1 inhibitor NAM

The dose-dependent response may be attributed to curcumin's complex interactions with multiple cellular targets and signaling pathways
