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77,78,83 Depletion of ALDH1L2 markedly decreases the NADPH/NADP + and GSH/GSSG ratios, reduces the circulating tumor cells in blood and alleviates the metastatic burden

Glutathione helps to detox many substances in the liver such as alcohol, as well as neutralize free radicals from other parts of the body

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Metabolomics analysis The samples were analyzed using ultra-high performance liquid chromatography (1,290 Infinity LC, Agilent Technologies, Santa Clara, California, USA) coupled to a quadrupole time-of-flight system (AB Sciex TripleTOF 6600, SCIEX, Redwood City, California, USA)

One way of screening for sensitivity to primaquine is based on the observation that the glutathione concentration of erythrocytes from sensitive subjects is somewhat lower than that of control subjects, and falls considerably on incubation with acetylphenylhydrazine