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About this article Cite this article El-Mansoury, B., Esselmani, H., Merzouki, M
Thus, the S-nitroso-acetyl-lipoate modification likely represents S-nitrosation occurring after the enzyme is inhibited at the acetylated state

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PARP-1 detects and signals DNA strand breaks induced by a variety of genotoxic insults, including ionizing radiations, alkylating agents, oxidants (essentially hydrogen peroxide, peroxynitrite, and possibly nitroxyl anion), and free radicals (mainly carbonate or hydroxyl radical) (299, 696, 1230)

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