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Mechanisms of Ageing and Development, 2004

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Most patients describe the experience as comfortable and relaxing

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Furthermore, heightened levels of lipid peroxidation markers and diminished antioxidant capacity have been discerned in the brains of individuals afflicted with neurodegenerative diseases [469, 470], suggesting a potential role of ferroptosis in the selective neuronal loss (Tables 5 & 6)

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Cancer Commun (Lond) 38(1):12

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Oxidative stress has been clarified to be related to the occurrence and progression of numerous diseases, including musculoskeletal diseases, cardiovascular diseases, respiratory diseases, dermatological diseases, neurodegenerative diseases, gastrointestinal diseases, cancer, and the aging process [7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22]

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Although there have been no previous reports on this pathway in IBS-C, studies have shown that in vitro experiments with IBS-D, gut microbiota can mediate the catabolism of dietary phenylalanine to produce phenethylamine, which activates the Trace Amine-Associated Receptor 1 (TAAR1) pathway to stimulate the synthesis of 5-HT4 in enterochromaffin cells, thereby promoting gastrointestinal motility and increasing colonic secretion ( Additionally, we found that the differential metabolite pyruvate was enriched in multiple metabolic pathways

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