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Mitochondrial metabolic reprogramming has emerged as a central adaptive mechanism that enables CRC cells to withstand hypoxia and therapeutic pressure, while concurrently driving resistance to chemotherapy, targeted agents, and immunotherapy

J Am Chem Soc 2022, 144 (47), 2162821639

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between the 2 strand and 2 helix) and to a final extension of 20 to 25 amino acids

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