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For Tirzepatide users specifically, GHK-Cu becomes relevant as weight loss progresses

The pharmacokinetic profile does not change with repeated administration

Endocrinologa y Nutricin (English Edition) 59(8):487490 Reinstatler L et al (2012) Association of biochemical B 12 deficiency with metformin therapy and vitamin B 12 supplements: the National Health and Nutrition Examination Survey, 19992006

Bioinformatics 2009, 25, 11891191

However, unlike ghrelin or older peptides, it avoids undesirable side effects making it one of the cleanest GH secretagogues available

These figures come from preclinical and pharmacokinetic literature, not from approved human dosing and note the standard route for this molecule is oral