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Hepatocarcinoma (LOE = B) Liver cancer, most commonly known as hepatocarcinoma, is a common malignancy, and treatment of this cancer with interferon-alpha 2A (IFN- ) has a relatively poor response rate of about 30%

It plays a critical role in two major global regulatory mechanisms, epigenetic modifications and imprinting, via methyl tagging on histones and DNA

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This phenomenon can induce a refractory response in melasma patients that can enhance the possibility of recurrence (Sanchez et al., 1981)