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The loss of these glands, along with duct blockages, increased oxidative stress, and heightened inflammatory responses, culminates in Meibomian gland dysfunctiona common contributor to DE disease

Even with microneedle introduction, liposome encapsulation or chemical penetration promoters (such as azone), its bioavailability is still difficult to reach an effective concentration

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[DOI] [PMC free article] [PubMed] [Google Scholar] Kysenius K, Muggalla P, Mtlik K, Arume U, Huttunen HJ, 2012