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They also built in parameters accounting for the fact that semaglutide, the key active ingredient in some leading GLP1RAs, is expected to lose patent protection around 2032, which could bring substantial price reductions

"Gentle, bland foods, such as oatmeal, might be tolerated better, as these tend to go down more easily when appetite is low or nausea is present," adds Vocca

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Retatrutide has a higher overall adverse event burden (6-10% discontinuation), partly because of the unique dysesthesia side effect at higher doses

In 2025, that meant it was impossible for me to scroll through my feed without being visually assaulted by ingratiating marketing campaigns, encouraging me to shed those last few pesky pounds via drugs, specifically off-label GLP-1