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But the primary concern is the risk of ochronosis, a rare but challenging condition where long-term overuse paradoxically causes darkening of the skin, says Francesa Lewis, MD, a board-certified dermatologist in Delray Beach, Florida

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Because studies have evaluated GHK-Cu across multiple cell types (including fibroblasts and keratinocytes) and in preclinical models, it is commonly used to support mechanistic work on aging-related tissue changes, repair biology, and copper homeostasisstrictly within controlled research designs

In terms of behavioral testing, Dihexa was assessed for its ability to reverse deficits induced by the administration of scopolamine, seen in the subjects performance in the water maze test