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In response to increasing oral doses of vitamin C, plasma vitamin C concentration rises steeply at intakes between 30 and 100 mg/day

From the skin: rash, itching, urticaria, exfoliative dermatitis, angioedema, acne

There is no receptor to desensitise on a fast clock, and no acute spike to time around a meal

Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial

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It is one that has numerous pathophysiological abnormalities, with a varying predisposition to complications and an assorted clinical response to therapeutic intervention
