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A key regulator of mitochondrial biogenesis is peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), which activates nuclear transcription factors NRF1 and NRF2, along with mitochondrial transcription factor A (TFAM)

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Abbreviations AMPK: AMP-dependent protein kinase Bcl-2: B-cell lymphoma-2 Bax: Bcl2-Associated X CDK2: Cyclin-dependent kinases 2 C10:2: Decadienyl-l-carnitine ETO: Etomoxir HSP47: Heat shock protein 47 IL-1: Interleukin-1 IL-18: Interleukin-18 MCT: Monocrotaline MMP2: Matrix metallopeptidase 2 MMP9: Matrix metallopeptidase 9 NLRP3: NOD-,LRR-and pyrin domain-containing protein 3 PASMCs: Pulmonary artery smooth muscle cells PCNA: Proliferating cell nuclear antigen PDGF-BB: Platelet-derived growth factor-BB PH: Pulmonary hypertension PVR: Pulmonary vascular remodeling ROS: Reactive oxygen species TGF-: Transforming growth factor References Ruopp NF, Cockrill BA

AMPK is a master regulator of cellular energy, switching on pathways that produce ATP (like glucose uptake and fatty acid oxidation) and switching off pathways that consume ATP (like lipid and protein synthesis) when energy levels are low