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PfB and BruB were shown to catalyze regioselective and stereoselective electrocyclization of polyene products from the respective PKS-NRPS, followed by either a [4+2] cycloaddition to give ()-PF-1018 ( 285 ), or [3,3]-Cope rearrangement to give 286 , respectively (Figure 62)

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The dysregulation of miR-103 may be a contributing factor for abnormal fatty acid metabolism in ASD, and miR-146a defects may lead to impaired phagocytosis in immune responses
Hartung, D

doi: 10.1186/s12934-020-01464-4 17 GudnadottirUDebeliusJWDuJHugerthLWDanielssonHSchuppe-KoistinenIet al

Giorgio Cozza, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
