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10.1038/nature04791 39 GrossmanE

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Cell Mol Neurobiol 43:27432759 [DOI] [PMC free article] [PubMed] [Google Scholar] Andrasson M, Brodin L, Laffita-Mesa JM, Svenningsson P (2017) Correlations between methionine cycle metabolism, COMT genotype, and polyneuropathy in L-dopa treated Parkinsons disease: a preliminary cross-sectional study

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The pattern is clear: promising preclinical research exists across many domains, but moving from animal models to demonstrated human benefit remains the central scientific challenge