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With a lifetime risk of approximately 78%, appendicitis represents a significant global healthcare concern
Silybin can counteract this by activating the deacetylase SIRT2 (likely through increasing intracellular NAD+ levels via downregulating PARP-1 expression)
[DOI] [PubMed] [Google Scholar] 55.Peng W., Novak N
However, higher concentrations may lead to adverse effects such as sperm agglutination, resulting in decreased motility [54, 55]
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