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By integrating total synthesis and late-stage modifications, they produced a library of novel TFs incorporating sequence mutations and site-specific staples derived from bHLH TFs, e.g., Max (Fig

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

& Jacobs, W

, AtkinsonDell R., Verkhratsky A., and Mohamet L

DOI: 10.1016/b978-012689663-3/50049-1

For the gut, they can help repair the intestinal lining, reduce inflammation, and support a healthy microbial balance
