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Thus, metformin may be beneficial by providing mild inhibition of complex I, because the reduced ATP/ADP ratio activates the AMPK signaling pathway, thereby promoting autophagy-mediated degradation of misfolded proteins and dysfunctional organelles [157]

Chan Y, Ng SW, Tan JZX, Gupta G, Negi P, Thangavelu L, Balusamy SR, Perumalsamy H, Yap WH, Singh SK, Caruso V, Dua K, Chellappan DK (2021) Natural products in the management of obesity: Fundamental mechanisms and pharmacotherapy

PLoS One 5 (12), e14476

Curr Pharm Des (2020) 26:263041

Farooq, M., Wahid, A., Kobayashi, N., Fujita, D

The midgut PAL dephosphorylating activity was monitored by the conversion of p-nitrophenyl phosphate p-NPP) into p-nitrophenol at 410 nm